Contraindicated (one)pentobarbital will decrease the level or outcome of cariprazine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. CYP3A4 is chargeable for the development and elimination of cariprazine's active metabolites.pentobarbital will reduce the extent or impact of meloxicam by impacting hepatic enzyme CYP2C9/10